Mir34a^tm1.2Aven
Targeted Allele Detail

Summary

• Symbol: Mir34a^tm1.2Aven
• Name: microRNA 34a; targeted mutation 1.2, Andrea Ventura
• MGI ID: MGI:5320795
• Synonyms: miR-34a^fl
• Gene: Mir34a Location: Chr4:150152911-150153012 bp, + strand Genetic Position: Chr4, 80.85 cM
• Alliance: Mir34a^tm1.2Aven page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188152
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of the sequence, and a frt-flanked neomycin resistance (neo) cassette, followed by a second loxP site, downstream of the sequence. Flp-mediated recombination removed the neo cassette and left the sequence floxed. (J:188152)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir34a Mutation: 9 strains or lines available

References

• Original: J:188152 Concepcion CP, et al., Intact p53-dependent responses in miR-34-deficient mice. PLoS Genet. 2012 Jul;8(7):e1002797
• All: 13 reference(s)