Igh^tm4.1Cog
Targeted Allele Detail

Summary

• Symbol: Igh^tm4.1Cog
• Name: immunoglobulin heavy chain complex; targeted mutation 4.1, Michel Cogne
• MGI ID: MGI:5320879
• Synonyms: alphadeltatail
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184094
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Mbalpha exon (Calpha membrane exon) was replaced with a loxP site flanked neomycin resistance gene cassette. Cre-mediated recombination removed the neo cassette. ELISA analysis confirmed the reduction in IgA protein expression. (J:184094)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:184094 Amin R, et al., Deletion of the alpha immunoglobulin chain membrane-anchoring region reduces but does not abolish IgA secretion. Immunology. 2012 May;136(1):54-63
• All: 1 reference(s)