Ddah1^tm1.1Yjch
Targeted Allele Detail

Summary

• Symbol: Ddah1^tm1.1Yjch
• Name: dimethylarginine dimethylaminohydrolase 1; targeted mutation 1.1, Yingjie Chen
• MGI ID: MGI:5424370
• Synonyms: DDAH1^-
• Gene: Ddah1 Location: Chr3:145464447-145600032 bp, + strand Genetic Position: Chr3, 70.63 cM, cytoband H3
• Alliance: Ddah1^tm1.1Yjch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182373
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 4 was deleted from Ddah1^tm1Yjch by germline cre-mediated recombination. No encoded protein was detected in tissue samples from kidney, brain, liver and lung of homozygous animals. (J:182373)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddah1 Mutation: 18 strains or lines available

References

• Original: J:182373 Hu X, et al., Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1540-6
• All: 7 reference(s)