Tent5a^m1Mhda
Chemically induced Allele Detail

Summary

• Symbol: Tent5a^m1Mhda
• Name: terminal nucleotidyltransferase 5A; mutation 1, Martin Hrabe de Angelis
• MGI ID: MGI:5424906
• Synonyms: bone alkaline phospatase mutant 014, Fam46a^BAP014, Fam46a^E157*
• Gene: Tent5a Location: Chr9:85202492-85209203 bp, - strand Genetic Position: Chr9, 46.04 cM
• Alliance: Tent5a^m1Mhda page

Reduced body size, and abnormal limb and bone phenotypes in Tent5a^m1Mhda/Tent5a^m1Mhda mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: This ENU-induced mutation was isolated in a screen for metabolic bone disease as part of the Munich ENU Mutagenesis Project. The molecular lesion is a G-to-T nonsense mutation (NM_001160378.1:c.469G>T) within the gene, leading to a premature stop codon after 156 amino acids of the encoded protein (NP_001153850.1:p.Glu157*). (J:230816)

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tent5a Mutation: 19 strains or lines available

References

• Original: J:183993 Sabrautzki S, et al., New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis. Mamm Genome. 2012 Aug;23(7-8):416-30
• All: 2 reference(s)