Alpl^Mhdabap27
Chemically induced Allele Detail

Summary

• Symbol: Alpl^Mhdabap27
• Name: alkaline phosphatase, liver/bone/kidney; Martin Hrabe de Angelis bone alkaline phospatase mutant 27
• MGI ID: MGI:5424923
• Synonyms: Alpl^BAP027
• Gene: Alpl Location: Chr4:137469044-137523695 bp, - strand Genetic Position: Chr4, 70.02 cM
• Alliance: Alpl^Mhdabap27 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This ENU-induced mutation was isolated in a screen for metabolic bone disease as part of the Munich ENU Mutagenesis Project. Missense mutation in exon 10 of the gene; an T-to-A point mutation at position 1194 of the cDNA is predicted to alter codon 395 in the encoded protein from a isoleucine to asparagine. (J:183993)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Alpl Mutation: 352 strains or lines available

References

• Original: J:183993 Sabrautzki S, et al., New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis. Mamm Genome. 2012 Aug;23(7-8):416-30
• All: 1 reference(s)