Casr^BCH007
Chemically induced Allele Detail

Summary

• Symbol: Casr^BCH007
• Name: calcium-sensing receptor; bone calcium high mutant 007
• MGI ID: MGI:5424982
• Gene: Casr Location: Chr16:36314058-36382503 bp, - strand Genetic Position: Chr16, 25.57 cM
• Alliance: Casr^BCH007 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This ENU-induced mutation was isolated in a screen for metabolic bone disease as part of the Munich ENU Mutagenesis Project. Missense mutation in exon 4 of the gene, a T-to-C point mutation at position 626 of the cDNA is predicted to alter codon 208 in the encoded protein from a valine to an alanine. (J:183993)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casr Mutation: 61 strains or lines available

References

• Original: J:183993 Sabrautzki S, et al., New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis. Mamm Genome. 2012 Aug;23(7-8):416-30
• All: 1 reference(s)