Zbtb18^tm1.1Nda
Targeted Allele Detail

Summary

• Symbol: Zbtb18^tm1.1Nda
• Name: zinc finger and BTB domain containing 18; targeted mutation 1.1, N Dahmane
• MGI ID: MGI:5425228
• Synonyms: RP58^fl
• Gene: Zbtb18 Location: Chr1:177269917-177278330 bp, + strand Genetic Position: Chr1, 82.72 cM, cytoband H3
• Alliance: Zbtb18^tm1.1Nda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184434
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in the 5' untranslated region and an FRT flanked neo cassette and loxP site were inserted in the 3' untranslated region via homologous recombination. Flp mediated recombination removed the neo cassette. (J:184434)

Disease models

Expression

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb18 Mutation: 26 strains or lines available

References

• Original: J:184434 Xiang C, et al., RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion. Cell Death Differ. 2012 Apr;19(4):692-702
• All: 3 reference(s)