Gli3^tm1.1Zllr
Targeted Allele Detail

Summary

• Symbol: Gli3^tm1.1Zllr
• Name: GLI-Kruppel family member GLI3; targeted mutation 1.1, Rolf Zeller
• MGI ID: MGI:5425255
• Synonyms: Gli3^f
• Gene: Gli3 Location: Chr13:15638308-15904611 bp, + strand Genetic Position: Chr13, 5.43 cM, cytoband A2
• Alliance: Gli3^tm1.1Zllr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184012
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A lox511 site, loxP site and FRT flanked neo cassette were inserted upstream of exon 11 and a loxP site, a splice acceptor site, IRES site, EGFP cassette, F3 flanked hygromycin cassette and lox2272 site were inserted downstream of exon 15. Flp mediated recombination removed the neo and hygromycin cassettes. (J:184012)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli3 Mutation: 81 strains or lines available

References

• Original: J:184012 Lopez-Rios J, et al., GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell. 2012 Apr 17;22(4):837-48
• All: 2 reference(s)