Gli3^tm1.2Zllr
Targeted Allele Detail

Summary

• Symbol: Gli3^tm1.2Zllr
• Name: GLI-Kruppel family member GLI3; targeted mutation 1.2, Rolf Zeller
• MGI ID: MGI:5425256
• Synonyms: Gli3^delta
• Gene: Gli3 Location: Chr13:15638308-15904611 bp, + strand Genetic Position: Chr13, 5.43 cM, cytoband A2
• Alliance: Gli3^tm1.2Zllr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184012
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lox511 site, loxP site and FRT flanked neo cassette were inserted upstream of exon 11 and a loxP site, a splice acceptor site, IRES site, EGFP cassette, F3 flanked hygromycin cassette and lox2272 site were inserted downstream of exon 15. Flp mediated recombination removed the neo and hygromycin cassettes. Cre mediated recombination removed exons 11 - 15. (J:184012)

Expression

In Mice Carrying this Mutation:	26 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli3 Mutation: 81 strains or lines available

References

• Original: J:184012 Lopez-Rios J, et al., GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell. 2012 Apr 17;22(4):837-48
• All: 3 reference(s)