Mns1^tm1Jw
Targeted Allele Detail

Summary

• Symbol: Mns1^tm1Jw
• Name: meiosis-specific nuclear structural protein 1; targeted mutation 1, Jeremy Wang
• MGI ID: MGI:5425368
• Gene: Mns1 Location: Chr9:72345276-72366036 bp, + strand Genetic Position: Chr9, 40.08 cM
• Alliance: Mns1^tm1Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183398
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 - 8 were replaced with a floxed neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in testes and trachea from homozygous mice. (J:183398)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mns1 Mutation: 20 strains or lines available

References

• Original: J:183398 Zhou J, et al., MNS1 is essential for spermiogenesis and motile ciliary functions in mice. PLoS Genet. 2012 Mar;8(3):e1002516
• All: 2 reference(s)