Mtor^tm1.2Seq
Targeted Allele Detail

Summary

• Symbol: Mtor^tm1.2Seq
• Name: mechanistic target of rapamycin kinase; targeted mutation 1.2, Susan E Quaggin
• MGI ID: MGI:5425404
• Synonyms: Mtor^del
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^tm1.2Seq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184667
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon1 and an FRT flanked PGK-neo cassette followed by a second loxP site was inserted in intron 3. The selection cassette was removed from properly targeted mice using flp recombinase leaving exons 1-3 flanked by loxP sites. Exons 1-2 were then removed by cre excision. (J:184667)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 115 strains or lines available

References

• Original: J:184667 Cina DP, et al., Inhibition of MTOR disrupts autophagic flux in podocytes. J Am Soc Nephrol. 2012 Mar;23(3):412-20
• All: 1 reference(s)