Pon3^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Pon3^tm1Tigm
• Name: paraoxonase 3; targeted mutation 1, Texas A&M Institute for Genomic Medicine
• MGI ID: MGI:5425686
• Gene: Pon3 Location: Chr6:5220852-5256286 bp, - strand Genetic Position: Chr6, 1.99 cM
• Alliance: Pon3^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184656
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first two coding exons were replaced with a beta-geo cassette. Western blot analysis confirms the absence of protein expression in the lung and liver. (J:184656)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pon3 Mutation: 24 strains or lines available

References

• Original: J:184656 Kempster SL, et al., Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice. Am J Physiol Endocrinol Metab. 2012 Jan;302(1):E103-7
• All: 1 reference(s)