Fgf20^tm1.1Dor
Targeted Allele Detail

Summary

• Symbol: Fgf20^tm1.1Dor
• Name: fibroblast growth factor 20; targeted mutation 1.1, David M Ornitz
• MGI ID: MGI:5425761
• Synonyms: Fgf20^betaGal, Fgf20^lacZ
• Gene: Fgf20 Location: Chr8:40732206-40740060 bp, - strand Genetic Position: Chr8, 23.89 cM, cytoband B1.2
• Alliance: Fgf20^tm1.1Dor page

Disorganization and loss of sensory cells in the Fgf20^tm1.1Dor/Fgf20^tm1.1Dor organ of Corti

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184501
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 1 was replaced with lacZ gene and floxed neo cassette. Cre-mediated recombination removed the neo cassette. RT-PCR confirmed the absence of transcript in the inner ear at E14.5. (J:184501)

Generation of the Fgf20^tm1.1Dor allele

Expression

In Mice Carrying this Mutation:	26 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf20 Mutation: 16 strains or lines available

References

• Original: J:184501 Huh SH, et al., Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 2012 Jan;10(1):e1001231
• All: 22 reference(s)