A4gnt^tm1Jnaka
Targeted Allele Detail

Summary

• Symbol: A4gnt^tm1Jnaka
• Name: alpha-1,4-N-acetylglucosaminyltransferase; targeted mutation 1, Jun Nakayama
• MGI ID: MGI:5425954
• Gene: A4gnt Location: Chr9:99494555-99504420 bp, + strand Genetic Position: Chr9, 51.91 cM
• Alliance: A4gnt^tm1Jnaka page

Hyperplasia, dysplasia and adenocarcinoma in A4gnt^tm1Jnaka/A4gnt^tm1Jnaka pyloric mucosa

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184485
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced the exon 2 and the coding sequence in exon 3. Immunohistochemistry confirmed the absence of protein expression in stomach and duodenum. (J:184485)

Generation of the A4gnt^tm1Jnaka allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying A4gnt^tm1Jnaka

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any A4gnt Mutation: 16 strains or lines available

References

• Original: J:184485 Karasawa F, et al., Essential role of gastric gland mucin in preventing gastric cancer in mice. J Clin Invest. 2012 Mar 1;122(3):923-34
• All: 1 reference(s)