Mstn^tm1.1Mgs
Targeted Allele Detail

Summary

• Symbol: Mstn^tm1.1Mgs
• Name: myostatin; targeted mutation 1.1, Michel Georges
• MGI ID: MGI:5425956
• Gene: Mstn Location: Chr1:53100799-53107238 bp, + strand Genetic Position: Chr1, 26.99 cM
• Alliance: Mstn^tm1.1Mgs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83122
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 3 and the neo cassette. RT-PCR confirmed the absence of transcript expression in skeletal muscle. (J:83122)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mstn Mutation: 34 strains or lines available

References

• Original: J:83122 Grobet L, et al., Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene. Genesis. 2003 Apr;35(4):227-38
• All: 7 reference(s)