Smad7^tm1.1Ink
Targeted Allele Detail

Summary

• Symbol: Smad7^tm1.1Ink
• Name: SMAD family member 7; targeted mutation 1.1, Ingo Kleiter
• MGI ID: MGI:5426017
• Synonyms: Smad7^fl
• Gene: Smad7 Location: Chr18:75500600-75529006 bp, + strand Genetic Position: Chr18, 51.06 cM, cytoband E2
• Alliance: Smad7^tm1.1Ink page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184670
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site followed by an frt-flanked neomycin (neo) resistance cassette upstream of the promoter regions and exon 1, and a second loxP site downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:184670)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smad7 Mutation: 53 strains or lines available

References

• Original: J:184670 Kleiter I, et al., Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain. 2010 Apr;133(Pt 4):1067-81
• All: 11 reference(s)