Hes7^tm2.1Dihz
Targeted Allele Detail

Summary

• Symbol: Hes7^tm2.1Dihz
• Name: hes family bHLH transcription factor 7; targeted mutation 2.1, David Ish-Horowicz
• MGI ID: MGI:5426214
• Synonyms: H10
• Gene: Hes7 Location: Chr11:69011230-69014881 bp, + strand Genetic Position: Chr11, 42.38 cM
• Alliance: Hes7^tm2.1Dihz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184024
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details: A 10 kb intronic fragment from human DMD that is not expected to contain cis-regulatory elements active in the mouse presomitic mesoderm was inserted into the third intron. Cre-mediated recombination removed the floxed neo cassette inserted upstream of the human sequence. (J:184024)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hes7 Mutation: 22 strains or lines available

References

• Original: J:184024 Stauber M, et al., Modifying transcript lengths of cycling mouse segmentation genes. Mech Dev. 2012 Mar;129(1-4):61-72
• All: 1 reference(s)