Tg(SRY-cre)1Svs
Transgene Detail

Summary

• Symbol: Tg(SRY-cre)1Svs
• Name: transgene insertion 1, David W Silversides
• MGI ID: MGI:5426227
• Synonyms: pSRYp[4.6kb]-Cre
• Transgene: Tg(SRY-cre)1Svs Location: unknown
• Alliance: Tg(SRY-cre)1Svs page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(SRY-cre)1Svs expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  pig, domestic	SRY

• Mutation details: A construct in which the 4.6 kb porcine SRY promoter drives expression of the cre recombinase sequence was microinjected into male pronuclei of single-celled FVB/N embryos. A second construct encoding a tyrosinase minigene was co-injected to facilitate identification of transgenic animals. Pigmented founders were bred to wild-type FVB/N mice to ensure single integration sites. Three founder lines were obtained and crossed to cre reporter ROSA-YFP mice to analyze cre activity in newborn tissues from double transgenic mice. The three lines displayed similar results and one line was propagated for further studies. (J:184604)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	SRY (pig, domestic) Summary of all recombinase alleles driven by SRY.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:184604 Silversides DW, et al., Transgenic mouse analysis of Sry expression during the pre- and peri-implantation stage. Dev Dyn. 2012 Jul;241(7):1192-204
• All: 1 reference(s)