Lepr^tm1Jke
Targeted Allele Detail

Summary

• Symbol: Lepr^tm1Jke
• Name: leptin receptor; targeted mutation 1, Joel K Elmquist
• MGI ID: MGI:5426228
• Synonyms: Lepr^loxTB
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^tm1Jke page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184572
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion A floxed transcription blocker was inserted into intron 16. (J:184572)

Generation of the Lepr^tm1Jke allele

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:184572 Berglund ED, et al., Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J Clin Invest. 2012 Mar 1;122(3):1000-9
• All: 19 reference(s)