Il17rb^tm1Tgi
Targeted Allele Detail

Summary

• Symbol: Il17rb^tm1Tgi
• Name: interleukin 17 receptor B; targeted mutation 1, Masaru Taniguchi
• MGI ID: MGI:5426267
• Synonyms: Il17rb^tm1Hwata
• Gene: Il17rb Location: Chr14:29718125-29730853 bp, - strand Genetic Position: Chr14, 18.39 cM
• Alliance: Il17rb^tm1Tgi page

Il17rb^tm1Tgi/Il17rb^tm1Tgi and Tcra-J^tm1Tgi/Tcra-J^tm1Tgi mice fail to exhibit airway hyperactivity in response to respiratory syncytial virus exposure

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184570
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette replaced the coding sequence in exon 1 and all of exon 2. Flow cytometry confirmed the absence of protein expression in the iNKT cells of the spleen. (J:184570)

Generation of the Il17rb^tm1Tgi allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il17rb Mutation: 42 strains or lines available

References

• Original: J:184570 Watarai H, et al., Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines. PLoS Biol. 2012 Feb;10(2):e1001255
• All: 4 reference(s)