Peg3^tm1.1Jkim
Targeted Allele Detail

Summary

• Symbol: Peg3^tm1.1Jkim
• Name: paternally expressed 3; targeted mutation 1.1, Joomyeong Kim
• MGI ID: MGI:5426383
• Gene: Peg3 Location: Chr7:6706891-6733430 bp, - strand Genetic Position: Chr7, 3.89 cM, cytoband A2-B1
• Alliance: Peg3^tm1.1Jkim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184471
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced two evolutionarily conserved elements (CSE1 and CSE2 or YY1-binding site) within the first intron. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed a 3- to 4-fold reduction in protein expression in the brain when this allele is paternally inherited. (J:184471)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Peg3 Mutation: 61 strains or lines available

References

• Original: J:184471 Kim J, et al., Imprinting control region (ICR) of the Peg3 domain. Hum Mol Genet. 2012 Jun 15;21(12):2677-87
• All: 1 reference(s)