Airn^tm2.1Dpb
Targeted Allele Detail

Summary

• Symbol: Airn^tm2.1Dpb
• Name: antisense Igf2r RNA; targeted mutation 2.1, Denise P Barlow
• MGI ID: MGI:5426385
• Synonyms: TDRdelta
• Gene: Airn Location: Chr17:12960198-13078771 bp, + strand Genetic Position: Chr17, 8.66 cM
• Alliance: Airn^tm2.1Dpb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183397
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The sequence encoding the tandem direct repeats (TDRs) were deleted. Cre-mediated recombination removed the upstream floxed neo cassette. (J:183397)

Generation of the Airn^tm2.1Dpb allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Airn Mutation: 4 strains or lines available

Notes

ES cell line = S12 (modified D3; 129S2/SvPas)

References

• Original: J:183397 Koerner MV, et al., A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter. PLoS Genet. 2012 Mar;8(3):e1002540
• All: 1 reference(s)