Spns2^tm1.1Nmoc
Targeted Allele Detail

Summary

• Symbol: Spns2^tm1.1Nmoc
• Name: SPNS lysolipid transporter 2, sphingosine-1-phosphate; targeted mutation 1.1, Naoki Mochizuki
• MGI ID: MGI:5426392
• Synonyms: Spns2^f
• Gene: Spns2 Location: Chr11:72342464-72380730 bp, - strand Genetic Position: Chr11, 44.31 cM
• Alliance: Spns2^tm1.1Nmoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184558
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination remove the neo cassette and left exon 2 floxed. (J:184558)

Generation of the Spns2^tm1.1Nmoc and Spns2^tm1.2Nmoc alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spns2 Mutation: 31 strains or lines available

References

• Original: J:184558 Fukuhara S, et al., The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest. 2012 Apr 2;122(4):1416-26
• All: 2 reference(s)