Spns2^tm1.2Nmoc
Targeted Allele Detail

Summary

• Symbol: Spns2^tm1.2Nmoc
• Name: SPNS lysolipid transporter 2, sphingosine-1-phosphate; targeted mutation 1.2, Naoki Mochizuki
• MGI ID: MGI:5426395
• Gene: Spns2 Location: Chr11:72342464-72380730 bp, - strand Genetic Position: Chr11, 44.31 cM
• Alliance: Spns2^tm1.2Nmoc page

Spns2^tm1.2Nmoc/Spns2^tm1.2Nmoc mice exhibit symblepharon

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184558
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination of Spns2^tm1.1Nmoc removes exon 2. RT-PCR confirmed the absence of full-length transcript. The protein product is expected to be functionally deffective. (J:184558)

Generation of the Spns2^tm1.1Nmoc and Spns2^tm1.2Nmoc alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spns2 Mutation: 31 strains or lines available

References

• Original: J:184558 Fukuhara S, et al., The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest. 2012 Apr 2;122(4):1416-26
• All: 1 reference(s)