Dck^memi
Chemically induced Allele Detail

Summary

• Symbol: Dck^memi
• Name: deoxycytidine kinase; memi
• MGI ID: MGI:5426400
• Synonyms: dCK^mem
• Gene: Dck Location: Chr5:88912872-88931136 bp, + strand Genetic Position: Chr5, 43.96 cM, cytoband E2
• Alliance: Dck^memi page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutations: Insertion, Single point mutation
• Mutation details: ENU mutagenesis induced a G to T transversion that results in the amino acid of a STOP codon for glutamic acid at position 247 (E247X). An enzymatic activity assay confirmed the absence of protein activity in the spleen. (J:184080)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dck Mutation: 20 strains or lines available

References

• Original: J:184080 Choi O, et al., A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival. J Immunol. 2012 Apr 15;188(8):3920-7
• All: 1 reference(s)