Dll1^tm1.1Hri
Targeted Allele Detail

Summary

• Symbol: Dll1^tm1.1Hri
• Name: delta like canonical Notch ligand 1; targeted mutation 1.1, Palle Serup
• MGI ID: MGI:5426508
• Synonyms: Dll1^f
• Gene: Dll1 Location: Chr17:15587616-15597134 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Dll1^tm1.1Hri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184814
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting construct was generated to introduce loxP sites flanking exons 3 and 4 of the Dll1 gene. An Frt-flanked neo selection marker was excised from the germline by Flp-e mediated recombination to produce the final allele. (J:184814)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dll1 Mutation: 46 strains or lines available

References

• Original: J:184814 Horn S, et al., Mind bomb 1 is required for pancreatic beta-cell formation. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7356-61
• All: 3 reference(s)