Arg1^tm1Ekoe
Targeted Allele Detail

Summary

• Symbol: Arg1^tm1Ekoe
• Name: arginase, liver; targeted mutation 1, Eleonore Kohler
• MGI ID: MGI:5426515
• Synonyms: Arg1^F
• Gene: Arg1 Location: Chr10:24791105-24803368 bp, - strand Genetic Position: Chr10, 12.26 cM
• Alliance: Arg1^tm1Ekoe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183882
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted upstream of exon 4. (J:183882)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arg1 Mutation: 28 strains or lines available

References

• Original: J:183882 Van den Bossche J, et al., Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes. J Leukoc Biol. 2012 May;91(5):685-99
• All: 4 reference(s)