Oma1^tm1Otin
Targeted Allele Detail

Summary

• Symbol: Oma1^tm1Otin
• Name: OMA1 zinc metallopeptidase; targeted mutation 1, Carlos Lopez-Otin
• MGI ID: MGI:5426689
• Synonyms: Oma1^tm1Otin
• Gene: Oma1 Location: Chr4:103171009-103229065 bp, + strand Genetic Position: Chr4, 47.6 cM, cytoband C6
• Alliance: Oma1^tm1Otin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184716
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neo cassette replaced exon 2. (J:184716)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oma1 Mutation: 23 strains or lines available

References

• Original: J:184716 Quiros PM, et al., Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J. 2012 May 2;31(9):2117-33
• All: 7 reference(s)