Lama1^tm1.1Arhi
Targeted Allele Detail

Summary

• Symbol: Lama1^tm1.1Arhi
• Name: laminin, alpha 1; targeted mutation 1.1, Eri Arikawa-Hirasawa
• MGI ID: MGI:5426811
• Synonyms: Lama1^flox
• Gene: Lama1 Location: Chr17:68004254-68129642 bp, + strand Genetic Position: Chr17, 38.8 cM
• Alliance: Lama1^tm1.1Arhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184432
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed PGK-neomycin cassette was inserted in intron 15 and a third loxP site was placed in intron 17. Cre expression resulted in mice in which either the floxed neo alone was removed leaving exons 16 and 17 flanked by loxP sites or in which the floxed neo and exons 16 and 17 were removed. (J:184432)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lama1 Mutation: 186 strains or lines available

References

• Original: J:184432 Ichikawa-Tomikawa N, et al., Laminin alpha1 is essential for mouse cerebellar development. Matrix Biol. 2012 Jan;31(1):17-28
• All: 2 reference(s)