Fcgr2b^tm1.1Rav
Targeted Allele Detail

Summary

• Symbol: Fcgr2b^tm1.1Rav
• Name: Fc receptor, IgG, low affinity IIb; targeted mutation 1.1, Jeffrey V Ravetch
• MGI ID: MGI:5426822
• Synonyms: Fcgr2b^fl
• Gene: Fcgr2b Location: Chr1:170786186-170804116 bp, - strand Genetic Position: Chr1, 78.02 cM
• Alliance: Fcgr2b^tm1.1Rav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183615
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of the exon encoding the first extracellular domain. A floxed neo cassette was inserted downstream of the exon encoding the transmembrane domain. Cre-mediated recombination removed the neo cassette. (J:183615, J:209892)

Generation of the Fcgr2b^tm1.1Rav allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr2b Mutation: 44 strains or lines available

Notes

ES cells containing this allele were used to generate Fcgr3^tm1Rav.

References

• Original: J:183615 Smith P, et al., Mouse model recapitulating human Fcgamma receptor structural and functional diversity. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6181-6
• All: 8 reference(s)