Tpx2^{Gt(D028B03)1.2Wrst}
Gene trapped Allele Detail

Summary

• Symbol: Tpx2^{Gt(D028B03)1.2Wrst}
• Name: TPX2, microtubule-associated; gene trap 1.2, German Gene Trap Consortium
• MGI ID: MGI:5426857
• Synonyms: Tpx2^delta
• Gene: Tpx2 Location: Chr2:152689884-152737241 bp, + strand Genetic Position: Chr2, 75.41 cM, cytoband H2
• Alliance: Tpx2^{Gt(D028B03)1.2Wrst} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184948
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Flp- and cre-mediated recombination of Tpx2^{Gt(D028B03)Wrst} inverted and reverted the gene trap. (J:184948)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpx2 Mutation: 110 strains or lines available

References

• Original: J:184948 Aguirre-Portoles C, et al., Tpx2 controls spindle integrity, genome stability, and tumor development. Cancer Res. 2012 Mar 15;72(6):1518-28
• All: 1 reference(s)