Rgs7^tm1Cjch
Targeted Allele Detail

Summary

• Symbol: Rgs7^tm1Cjch
• Name: regulator of G protein signaling 7; targeted mutation 1, Ching-Kang Chen
• MGI ID: MGI:5426905
• Gene: Rgs7 Location: Chr1:174886653-175320066 bp, - strand Genetic Position: Chr1, 81.11 cM
• Alliance: Rgs7^tm1Cjch page

Rgs7^tm1Cjch/Rgs7^tm1Cjch Rgs11^tm1Lex/Rgs11^tm1Lex mice have no ERG b-waves and contain ultrastructural defects in the retinal outer plexiform layer

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exons 6 through 8. Western blot analysis confirmed the absence of protein expression in the retina and cerebellum. (J:184922)

Generation of the Rgs7^tm1Cjch allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs7 Mutation: 26 strains or lines available

References

• Original: J:184922 Shim H, et al., Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice. J Biol Chem. 2012 Apr 27;287(18):14873-9
• All: 1 reference(s)