Cc2d1a^tm1Bisu
Targeted Allele Detail

Summary

• Symbol: Cc2d1a^tm1Bisu
• Name: coiled-coil and C2 domain containing 1A; targeted mutation 1, Bing Su
• MGI ID: MGI:5426910
• Gene: Cc2d1a Location: Chr8:84859457-84874546 bp, - strand Genetic Position: Chr8, 40.32 cM
• Alliance: Cc2d1a^tm1Bisu page

Small size and hunched back of Cc2d1a^tm1Bisu/Cc2d1a^tm1Bisu newborns

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184920
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exons 8 through 14. Western blot analysis confirmed the absence of full-length protein expression in macrophage, neurons and mouse embryonic fibroblast. (J:184920)

Targeting strategy to generate the Cc2d1a^tm1Bisu allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cc2d1a Mutation: 32 strains or lines available

References

• Original: J:184920 Al-Tawashi A, et al., Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity. J Biol Chem. 2012 Apr 27;287(18):14644-58
• All: 1 reference(s)