Gt(ROSA)26Sor^{tm50(HTT)Arte}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm50(HTT)Arte}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 50, TaconicArtemis
• MGI ID: MGI:5426930
• Synonyms: N463-Q148
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm50(HTT)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147112
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, RMCE-ready)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm50(HTT)Arte} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

  Expresses human HTT (145Q) truncated at position aa A463

• Mutation details: A cDNA construct carrying mutant human Huntington gene (145Q) truncated at position aa A463 (calpainII site) under the control of the CMV early enhancer/chicken beta actin promoter was targeted into Gt(ROSA)26Sor locus by RMCE. (J:147112, J:243843)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:147112 Taconic, Information obtained from Taconic website. MGI Direct Data Submission. 2006-2017
• All: 2 reference(s)