Soat2^tm1.1Llr
Targeted Allele Detail

Summary

• Symbol: Soat2^tm1.1Llr
• Name: sterol O-acyltransferase 2; targeted mutation 1.1, Lawrence L Rudel
• MGI ID: MGI:5426949
• Synonyms: ACAT2^fl, Acat2^tm1.1Lrud, Soat2^tm1.1Lrud
• Gene: Soat2 Location: Chr15:102058961-102071904 bp, + strand Genetic Position: Chr15, 57.33 cM
• Alliance: Soat2^tm1.1Llr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184908
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Flp-mediated recombination of Acat2^tm1Lrud removed the neo cassette and left exons 11 through 13 floxed. (J:184908)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Soat2 Mutation: 40 strains or lines available

References

• Original: J:184908 Zhang J, et al., Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood. J Lipid Res. 2012 Jun;53(6):1144-52
• All: 2 reference(s)