Flt4^tm1.1Sgo
Targeted Allele Detail

Summary

• Symbol: Flt4^tm1.1Sgo
• Name: FMS-like tyrosine kinase 4; targeted mutation 1.1, Sagrario Ortega
• MGI ID: MGI:5426966
• Synonyms: Vegfr3^EGFPLuc
• Gene: Flt4 Location: Chr11:49500506-49543566 bp, + strand Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
• Alliance: Flt4^tm1.1Sgo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183610
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Reporter) Mutation: Insertion Mutation details: A floxed neo cassette and IRES-EGFPLuc were inserted in the 3' UTR. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed normal protein expression levels. (J:183610)

Generation of the Flt4^tm1.1Sgo allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flt4 Mutation: 78 strains or lines available

References

• Original: J:183610 Martinez-Corral I, et al., In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6223-8
• All: 3 reference(s)