Cdh1^tm2.1Mpst
Targeted Allele Detail

Summary

• Symbol: Cdh1^tm2.1Mpst
• Name: cadherin 1; targeted mutation 2.1, Marc P Stemmler
• MGI ID: MGI:5426968
• Synonyms: NcEc ki
• Gene: Cdh1 Location: Chr8:107329983-107396878 bp, + strand Genetic Position: Chr8, 53.18 cM, cytoband D
• Alliance: Cdh1^tm2.1Mpst page

Cdh1^tm2.1Mpst/Cdh1^tm2.1Mpst embryos cannot form a trophectoderm layer

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183847
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Inserted expressed sequence) Mutations: Insertion, Intragenic deletion Mutation details: An expression vector encoding the N-terminal extracellular domain of Cdh2 fused to the C-terminal intracellular domain of Cdh1, HA tag, polyadenylation sequence and floxed neo cassette was inserted downstream of the translation initiation site. Cre-mediated recombination removed the neo cassette. (J:183847)

Generation of the Cdh1^tm2.1Mpst allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh1 Mutation: 173 strains or lines available

References

• Original: J:183847 Bedzhov I, et al., Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin. PLoS Genet. 2012 Mar;8(3):e1002609
• All: 1 reference(s)