About   Help   FAQ
Cdh1tm3.1Mpst
Targeted Allele Detail
Summary
Symbol: Cdh1tm3.1Mpst
Name: cadherin 1; targeted mutation 3.1, Marc P Stemmler
MGI ID: MGI:5426969
Synonyms: EcNc ki
Gene: Cdh1  Location: Chr8:107329983-107396878 bp, + strand  Genetic Position: Chr8, 53.18 cM, cytoband D
Alliance: Cdh1tm3.1Mpst page
Cdh1tm3.1Mpst/Cdh1tm3.1Mpst embryos fail to form a functional trophectoderm

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:183847
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn expression vector encoding the N-terminal extracellular domain of Cdh1 fused to the C-terminal intracellular domain of Cdh2, HA tag, polyadenylation sequence and floxed neo cassette was inserted downstream of the translation initiation site. Cre-mediated recombination removed the neo cassette. (J:183847)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh1 Mutation:  173 strains or lines available
References
Original:  J:183847 Bedzhov I, et al., Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin. PLoS Genet. 2012 Mar;8(3):e1002609
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory