Cdh1tm3.1Mpst
Targeted Allele Detail
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Symbol: |
Cdh1tm3.1Mpst |
Name: |
cadherin 1; targeted mutation 3.1, Marc P Stemmler |
MGI ID: |
MGI:5426969 |
Synonyms: |
EcNc ki |
Gene: |
Cdh1 Location: Chr8:107329983-107396878 bp, + strand Genetic Position: Chr8, 53.18 cM, cytoband D
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Alliance: |
Cdh1tm3.1Mpst page
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Cdh1tm3.1Mpst/Cdh1tm3.1Mpst embryos fail to form a functional trophectoderm
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:183847
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inserted expressed sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An expression vector encoding the N-terminal extracellular domain of Cdh1 fused to the C-terminal intracellular domain of Cdh2, HA tag, polyadenylation sequence and floxed neo cassette was inserted downstream of the translation initiation site. Cre-mediated recombination removed the neo cassette.
(J:183847)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cdh1 Mutation: |
173 strains or lines available
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Original: |
J:183847 Bedzhov I, et al., Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin. PLoS Genet. 2012 Mar;8(3):e1002609 |
All: |
1 reference(s) |
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