Nr1h3^tm1.1Djm
Targeted Allele Detail

Summary

• Symbol: Nr1h3^tm1.1Djm
• Name: nuclear receptor subfamily 1, group H, member 3; targeted mutation 1.1, David J Mangelsdorf
• MGI ID: MGI:5426973
• Synonyms: Lxra^fl
• Gene: Nr1h3 Location: Chr2:91014406-91033179 bp, - strand Genetic Position: Chr2, 50.52 cM
• Alliance: Nr1h3^tm1.1Djm page

Atherosclerosis lesion area is increased in Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice and TO901317 treatment reduces these lesions

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184536
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exons 4 and 5 floxed. (J:184536)

Generation of the Nr1h3^tm1.1Djm allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr1h3 Mutation: 32 strains or lines available

References

• Original: J:184536 Zhang Y, et al., Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest. 2012 May 1;122(5):1688-99
• All: 12 reference(s)