Bscl2^tm1.1Lchan
Targeted Allele Detail

Summary

• Symbol: Bscl2^tm1.1Lchan
• Name: BSCL2 lipid droplet biogenesis associated, seipin; targeted mutation 1.1, Lawrence Chan
• MGI ID: MGI:5426998
• Synonyms: Bscl2^neofldelta3, gBscl2^-
• Gene: Bscl2 Location: Chr19:8814831-8826047 bp, + strand Genetic Position: Chr19, 5.76 cM
• Alliance: Bscl2^tm1.1Lchan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183701
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Bscl2^tm1Lchan removed exon 3. qPCR confirmed the absence of transcript in epididymal white adipose tissue, subcutaneous white adipose tissue and brown adipose tissue. (J:183701)

Disease models

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bscl2 Mutation: 36 strains or lines available

References

• Original: J:183701 Chen W, et al., Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation. Mol Cell Biol. 2012 Mar;32(6):1099-111
• All: 12 reference(s)