Gpm6a^tm1.1Tahi
Targeted Allele Detail

Summary

• Symbol: Gpm6a^tm1.1Tahi
• Name: glycoprotein m6a; targeted mutation 1.1, Tatsumi Hirata
• MGI ID: MGI:5427086
• Synonyms: M6a^-
• Gene: Gpm6a Location: Chr8:55407878-55513906 bp, + strand Genetic Position: Chr8, 29.33 cM, cytoband B3.2
• Alliance: Gpm6a^tm1.1Tahi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184737
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a floxed PGK-neomycin selection cassette. The selection cassette was removed from properly targeted mice by cr excision. Removal of exon 2 causes a downstream frame shift and only short, non-functional, N-terminal peptides ar produced. (J:184737)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpm6a Mutation: 27 strains or lines available

References

• Original: J:184737 Sato Y, et al., Induction of axon growth arrest without growth cone collapse through the N-terminal region of four-transmembrane glycoprotein M6a. Dev Neurobiol. 2011 Sep;71(9):733-46
• All: 3 reference(s)