Del(16Lipi-Usp25)1Dja
Targeted Allele Detail

Summary

• Symbol: Del(16Lipi-Usp25)1Dja
• Name: deletion, Chr 16, David J Adams 1
• MGI ID: MGI:5427092
• Synonyms: Del1Dja, Deluca, Ms(Lipi-Usp25)1Dja
• Gene: Del(16Lipi-Usp25)1Dja Location: Chr16:75337402-76913667 bp Genetic Position: Chr16, Syntenic

Small size and increased apoptosis in Del(16Lipi-Usp25)1Dja/Del(16Lipi-Usp25)1Dja embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184302
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted Mutations: Insertion, Intergenic deletion, Intragenic deletion Del(16Lipi-Usp25)1Dja involves 17 genes/genome features (Gm22923, Lipi, Rbm11 ...) View all Mutation details: The deletion arose from cre-mediated recombination of ES cells containing, in cis, the MICER clone MHPN69h23 (neo cassette, flox and 5' Hprt minigene inserted upstream of Lipi) and a targeting vector that inserts a puro cassette, loxP site and 3' Hprt minigene downstream of Usp25. The deletion removed 6 genes including Lipi, Gm1745, Rbm1, Hspa1, Samsn1, Nrip1 and Usp25. (J:184302)

Generating a 1.6 MB deletion between Lipi and Usp25 loci creates the Del(16Lipi-Usp25)1Dja allele

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(16Lipi-Usp25)1Dja Mutation: 0 strains or lines available

References

• Original: J:184302 Migdalska AM, et al., Modeling partial monosomy for human chromosome 21q11.2-q21.1 reveals haploinsufficient genes influencing behavior and fat deposition. PLoS One. 2012;7(1):e29681
• All: 1 reference(s)