Tmc1^tm1.1Ajg
Targeted Allele Detail

Summary

• Symbol: Tmc1^tm1.1Ajg
• Name: transmembrane channel-like gene family 1; targeted mutation 1.1, Andrew J Griffith
• MGI ID: MGI:5427097
• Synonyms: Tmc1^delta
• Gene: Tmc1 Location: Chr19:20760822-20931566 bp, - strand Genetic Position: Chr19, 13.98 cM, cytoband B
• Alliance: Tmc1^tm1.1Ajg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184419
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 and 9 were replaced with an IRES-lacZ cassette and a floxed pgk-neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. At P28 beta-galactosidase activity is detected in both type I and type II hair cells of the saccular macula, utricular macula, and cristae ampullaris. (J:184419)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tmc1 Mutation: 59 strains or lines available

References

• Original: J:184419 Kawashima Y, et al., Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. J Clin Invest. 2011 Dec;121(12):4796-809
• All: 25 reference(s)