Tmc2^tm1.1Ajg
Targeted Allele Detail

Summary

• Symbol: Tmc2^tm1.1Ajg
• Name: transmembrane channel-like gene family 2; targeted mutation 1.1, Andrew J Griffith
• MGI ID: MGI:5427099
• Synonyms: Tmc2^delta
• Gene: Tmc2 Location: Chr2:130037114-130106365 bp, + strand Genetic Position: Chr2, 63.19 cM
• Alliance: Tmc2^tm1.1Ajg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184419
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7 was replaced with an IRES-lacZ cassette and a floxed pgk-neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. At P28 beta-galactosidase activity is detected in hair cells of the cristae ampullaris and very faintly in in hair cells of the saccular and utricular maculae. (J:184419)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tmc2 Mutation: 42 strains or lines available

References

• Original: J:184419 Kawashima Y, et al., Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. J Clin Invest. 2011 Dec;121(12):4796-809
• All: 18 reference(s)