Smarca1^tm1.1Pick
Targeted Allele Detail

Summary

• Symbol: Smarca1^tm1.1Pick
• Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; targeted mutation 1.1, David J Picketts
• MGI ID: MGI:5427348
• Synonyms: Ex6DEL, Snf2l Ex6DEL
• Gene: Smarca1 Location: ChrX:46898247-46981490 bp, - strand Genetic Position: ChrX, 25.41 cM, cytoband A3.2
• Alliance: Smarca1^tm1.1Pick page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183998
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of exon 6 and a loxP site was inserted downstream of exon 6 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 6. The mutant allele produces a stable transcript and a protein product that is 7 kDa smaller than the wild-type protein. (J:183998)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smarca1 Mutation: 12 strains or lines available

References

• Original: J:183998 Yip DJ, et al., Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain. Dev Cell. 2012 Apr 17;22(4):871-8
• All: 3 reference(s)