Bdnf^tm1.1Krj
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1.1Krj
• Name: brain derived neurotrophic factor; targeted mutation 1.1, Kevin R Jones
• MGI ID: MGI:5427360
• Synonyms: BDNF-LacZ
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1.1Krj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184139
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 and a trimerized downstream polyadenylation signal were removed by cre excision. The resulting mice are expected to express lacZ in place of Bdnf. (J:184139)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:184139 Kaneko M, et al., Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation. J Neurosci. 2012 Apr 4;32(14):4790-802
• All: 3 reference(s)