Cacfd1^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Cacfd1^tm1.1Geno
• Name: calcium channel flower domain containing 1; targeted mutation 1.1, Genoway
• MGI ID: MGI:5427429
• Synonyms: mFwe^deltaex3
• Gene: Cacfd1 Location: Chr2:26899938-26911101 bp, + strand Genetic Position: Chr2, 19.17 cM, cytoband A3
• Alliance: Cacfd1^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the floxed exon 3 and neo cassette. The truncated protein product is expected to be nonfunctional because it is not exposed to the cell surface. (J:184968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacfd1 Mutation: 16 strains or lines available

References

• Original: J:184968 Petrova E, et al., Flower-deficient mice have reduced susceptibility to skin papilloma formation. Dis Model Mech. 2012 Jul;5(4):553-61
• All: 1 reference(s)