Crat^tm1.1Pbrc
Targeted Allele Detail

Summary

• Symbol: Crat^tm1.1Pbrc
• Name: carnitine acetyltransferase; targeted mutation 1, Pennington Biomedical Research Center
• MGI ID: MGI:5427430
• Synonyms: Crat^fl
• Gene: Crat Location: Chr2:30290483-30305602 bp, - strand Genetic Position: Chr2, 21.69 cM
• Alliance: Crat^tm1.1Pbrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184778
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 8 and a floxed neo cassette was inserted into intron 11 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:184778)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crat Mutation: 46 strains or lines available

References

• Original: J:184778 Muoio DM, et al., Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metab. 2012 May 2;15(5):764-77
• All: 12 reference(s)