Ogn^tm1Hds
Targeted Allele Detail

Summary

• Symbol: Ogn^tm1Hds
• Name: osteoglycin; targeted mutation 1, Huai-Dong Song
• MGI ID: MGI:5427433
• Synonyms: mimecan KO
• Gene: Ogn Location: Chr13:49761522-49777977 bp, + strand Genetic Position: Chr13, 25.34 cM
• Alliance: Ogn^tm1Hds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183738
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replace exons 5 and 6. (J:183738)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ogn^tm1Hds/Ogn^tm1Hds	B6.129S1-Ogn^tm1Hds

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
homeostasis/metabolism	√
abnormal adrenocorticotropin level	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ogn Mutation: 20 strains or lines available

References

• Original: J:183738 Ma QY, et al., Mimecan in pituitary corticotroph cells may regulate ACTH secretion and the HPAA. Mol Cell Endocrinol. 2011 Jul 20;341(1-2):71-7
• All: 2 reference(s)