Pnpla2^tm1Gam
Targeted Allele Detail

Summary

• Symbol: Pnpla2^tm1Gam
• Name: patatin-like phospholipase domain containing 2; targeted mutation 1, Grant A Mitchell
• MGI ID: MGI:5427437
• Gene: Pnpla2 Location: Chr7:141035111-141040656 bp, + strand Genetic Position: Chr7, 86.81 cM, cytoband F5
• Alliance: Pnpla2^tm1Gam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185116
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. (J:185116)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnpla2 Mutation: 33 strains or lines available

References

• Original: J:185116 Wu JW, et al., Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology. 2011 Jul;54(1):122-32
• All: 5 reference(s)